Facilities
Genomics and Bioinformatics Core Facilities at Cornell
Genomics requires access to advance and ever-changing technology to generate and to analyze data. At Cornell, we have outstanding core facilities available to faculty, staff, students and postdocs doing or planning genomic analysis of all scales and organisms.
Outstanding, state-of-the-art Genomics shared core facilities are provided by Cornell’s Biotechnology Resource Center (BRC) which maintains an array of genomic, proteomics, imaging and informatics shared research resources and Core Laboratory services to the university community.
Genomics Facility (RRID:SCR_021727) provides a broad array of instrumentation and services, including Sanger Big Dye Terminator sequencing of plasmid and PCR products, fragment analysis (microsatellites), Next-Generation sample preparation and QC, Next-Generation sequencing using and a range of next generation sequencing instruments, including Illumina and MinION (Oxford Nanopore) platforms. They also have a number of user-operated instruments available including digital and real-time PCR.
Transcription Regulation and Expression Facility (TREx) (RRID:SCR_022532) offers end-to-end genomics profiling services. RNA-Seq, small-RNA sequencing, and ATAC-Seq packages include library preparation, sequencing, and standard data analysis. RNA-Seq library options include directional (stranded) or standard libraries, with pre-enrichment options including polyA+ selection and rRNA depletion (HMR and/or bacteria). Standard analyses includes preprocessing/QC, mapping, and differential expression analysis.
Epigenomics Facility (RRID:SCR_021287) provides Epigenomics using ChIP-exo, ATAC-Seq, or ChIP-Seq.
Genomics Innovation Hub (RRID:SCR_022547) provides collaborative expertise, tools and funding for genomics technology development.
Bioinfomatics Facility (RRID:SCR_021757) offers resources, services and training in computational biology and bioinformatics through collaborative research and consultation, and by providing easily accessible advanced computational software, data storage and analysis platforms and expertise in their use and applications.
Related Core Facilities at Cornell
Imaging Facility (RRID:SCR_021741) resources and services include high resolution X-ray computed tomography (CT), confocal microscopy, light microscopy, multiphoton microscopy, laser capture microdissection, bioluminescence imaging, high resolution ultrasound imaging, spectrofluorometry, and image visualization and analysis software. The facility also provides consultation on project design, instrument use, and image data analysis and visualization, and offers educational workshops and training.
Flow Cytometry Facility (RRID:SCR_021740) maintains an expansive suite of sorters and analyzers as well as educational programming and consultation.
Proteomics and Metabolomics Facility (RRID:SCR_021743) provides investigators with cutting edge technologies for proteomic and metabolomics analyses. Proteomics services include 2D gel and 2D LC separation for macromolecules; robotic and manual sample preparation for proteomics samples; protein identification; quantitative proteomics; and characterization of post-translational modifications (PTMs) through both non-targeted and targeted discovery approaches. Metabolomics services include untargeted metabolomics profiling for discovery screens, metabolic flux analysis, Targeted metabolomics profiling for validation, Targeted small molecules analysis for relative/absolute quantitation, metabolite separation, and sample preparation. Consultation is always available for experimental design and data analysis/interpretation.