Tuesday, December 07, 2010
Andrew Clark (MBG/EEB) and Alon Keinan (BSCB), both 3CPG faculty members, lead parts of international effort to sequence and analyze more than 2,500 human genomes from 27 populations worldwide as part of the “1,000 Genomes Project”. Clark is a co-PI for the major international research project and member of the steering committee, and his group has developed and contributed new sophisticated statistical analysis methods to quantify and characterize the DNA sequence diversity. Keinan and his group has been involved in designing the global sampling of human populations and statistically analyzing differences in variation associated with different human chromosomes.
See Cornell Chronicle article and recent article co-authored by Clark and Keinan in Nature (467:1061-1072; 2010) summarizing initial results, including the finding that "on average, each person is found o carry approsimately 250 to 300 loss-of-function variants in annotated genes and 50 to 100 variants previously implicated in inherited disorders.".